MACPHERSON, Janet,PERITT, David,HENRICHSEN, Kevin,SYMONDS, Geoffrey,POND, Susan,WONG, Philip
申请号：
ES09810835
公开号：
ES2606236T3
申请日:
2009.12.15
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
An apparatus for processing blood, said apparatus comprising: an input interface for engaging with a patient in order to receive blood directly from the circulation of said patient； a leukapheresis module coupled to said input interface to collect mononuclear blood cells in bulk from said received blood； an enrichment module coupled to said leukapheresis module to enrich target cells concurrently separated from non-target cells in said bulk mononuclear blood cells； a modification module of the target cells adapted to provide a modification selected from the group consisting of activation of cytotoxic T lymphocytes (CTL)； activation of regulatory T lymphocytes (Treg) and genetically modified blood cells protected from human immunodeficiency virus (HIV) linked to at least one of said leukapheresis module and said enrichment module, said modifying module modifying said enriched target cells； an output interface coupled to at least one of said leukapheresis module and said enrichment module to couple with said patient to return enriched target cells to the circulation of said patient； said apparatus and said patient forming a closed circuit when coupled together； and a controller for automatic control of the operation of said input and output interfaces, said leukapheresis module and said enrichment module.Un aparato para procesar sangre, comprendiendo dicho aparato: una interfaz de entrada para acoplarse con un paciente a fin de recibir sangre directamente de la circulación de dicho paciente； un módulo de leucaféresis acoplado a dicha interfaz de entrada para recolectar células sanguíneas mononucleares a granel a partir de dicha sangre recibida； un módulo de enriquecimiento acoplado a dicho módulo de leucaféresis para enriquecer células diana concurrentemente separadas de las células que no son diana en dichas células sanguíneas mononucleares a granel； un módulo de modificación de las células diana adaptado para proporcionar una modificación seleccionada del grupo que
