CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN;President and Fellows of Harvard College
发明人:
Pascal Joly,Georg N. Duda,Thomas Schaus,Anke Dienelt,Andrea Sass,David J. Mooney
申请号：
US15580710
公开号：
US20180185417A1
申请日:
2016.06.09
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention is directed to a device for enriching cells with a cell surface marker, comprising an aptamer suitable for specifically binding the cell surface marker, and beads coupled thereto, wherein the aptamer is coupled to the beads in a manner that allows for release of cells expressing the cell surface marker, in the absence of a chemical agent, and production of a cell population enriched for cells expressing the cell surface marker, substantially free of beads and aptamer. Kits comprising the device or components thereof, and methods of cell enrichment, are also provided. In exemplary embodiments, the device contains an aptamer that specifically binds CD31.
