PERITT DAVID,SYMONDS GEOFFREY PHILLIP,HENRICHSEN KEVIN,MACPHERSON JANET LESLEY,WONG PHILIP,POND SUSAN
申请号：
NZ59285309
公开号：
NZ592853A
申请日:
2009.12.15
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
592853 An apparatus for processing blood to treat human immunodeficiency virus (HIV). The apparatus includes an inlet interface for coupling with a patient to receive blood directly from the circulation of the patient, a leukapheresis module coupled to the inlet interface for collecting bulk mononuclear blood cells from the received blood and an enrichment module coupled to the leukapheresis module for enriching concurrently target cells separated from non-target cells in the bulk mononuclear blood cells. The apparatus includes a target-cell modification module adapted to provide modification selected from the group consisting of cytotoxic T lymphocyte (CTL) activation, T regulatory cell (Treg) activation, and genetically modified blood cells protected from human immunodeficiency virus (HIV). The modification module is coupled to one of the leukapheresis module and the enrichment module. The modification module modifies the enriched target cells. The apparatus further includes an outlet interface coupled to one of the leukapheresis module and the enrichment module. The outlet interface couples with the patient to return enriched target cells to the circulation of the patient. The apparatus and the patient form a closed loop when coupled together. The apparatus includes a controller for automated control of operation of the inlet and outlet interfaces, the leukapheresis module, and the enrichment module.
