Richard Malley,Porter Anderson,Yingjie Lu,George A. Robertson,Mark Alderson,Jean-Francois Lucien Maisonneuve,Andrea Maria Tate,Waldely de Oliveira Dias,Viviane Maimoni Gonçalves
申请号：
US13500925
公开号：
US20120251577A1
申请日:
2010.10.12
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention provides for immunogenic compositions and methods for producing an immunogenic composition with multiple immunity-inducing fractions of killed, whole-cell Streptococcus pneumoniae by selectively disrupting a whole cell bacterial preparation in such a manner that a soluble fraction that induces a primarily antibody response, and a cellular fraction that induces a primarily antibody-independent response, remain in the immunogenic composition.
