MALLEY, RICHARD,ANDERSON, PORTER,LU, YINGJIE,ALDERSON, MARK,ROBERTSON, GEORGE A.,MAISONNEUVE, JEAN-FRANCOIS LUCIEN,TATE, ANDREA MARIA,DE OLIVEIRA DIAS, WALDELY,MIAMONI GONCALVES, VIVIANE
申请号：
EP10822835
公开号：
EP2485764A4
申请日:
2010.10.12
申请国别(地区):
EP
年份:
2014
代理人:
摘要：
The present invention provides for immunogenic compositions and methods for producing an immunogenic composition with multiple immunity-inducing fractions of killed, whole-cell Streptococcus pneumoniae by selectively disrupting a whole cell bacterial preparation in such a manner that a soluble fraction that induces a primarily antibody response, and a cellular fraction that induces a primarily antibody-independent response, remain in the immunogenic composition.
