WISNIEWSKI, Kazimierz,HARRIS, Geoffrey S.,GALYEAN, Robert Felix
申请号：
ES13729826
公开号：
ES2571928T3
申请日:
2013.05.09
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
Compound according to formula (I): ** Formula ** or a salt thereof, wherein: R1 is selected from (C1-C10) alkyl, (C1-C10) alkoxy, (C1-C10) -NH alkyl, Ar1-L1- and unsubstituted or substituted cycloalkyl, Ar1-L1- is selected from Ar1-, Ar1-CH2-, Ar1-CH2CH2-, Ar1-O-, Ar1-CH2O-, Ar1-NH- and Ar1-CH2NH- ； Ar1 is unsubstituted aryl or substituted aryl； R2 is selected from hydrogen, (C1-C6) alkyl, hydroxyl, (C1-C6) alkoxy and halogen； R3 is selected from (C1-C6) alkyl, unsubstituted or substituted cycloalkyl and Cy3-CH2-； Cy3- is unsubstituted or substituted aryl or unsubstituted or substituted cycloalkyl； R4 is selected from alkyl (C1-C6), alkenyl (C2-C6), alkynyl (C2-C6), haloalkyl (C1-C6), - (alkylene (C1-C6)) - OR4a, - (alkylene (C1- C6)) - NR4a2, - (alkylene (C1-C6)) - S-alkyl (C1-C6), - (alkylene (C1-C6)) - C (>； = O) OR4a2, - (alkylene (C1-C6) )) - C (>； = O) NR4a2, - (alkylene (C1-C6)) - C (>； = NR4a) NR4a2, - (alkylene (C1-C6)) - OC (>； = O) R4a, - (alkylene (C1-C6)) - OC (>； = O) OR4a, - (rent (C1-C6)) - OC (>； = O) NR4a2, - (rent (C1-C6)) - NR4aC (>； = O) R4a , - (alkylene (C1-C6)) - NR4aC (>； = O) OR4a, - (alkylene (C1-C6)) - NR4aC (>； = O) NR4a2, - (alkylene (C1-C6)) - NR4aC (>； = NR4a) NR4a2, Ar4 and - (alkylene (C1-C6)) - Ar4； each R4a is independently selected from hydrogen and (C1-C6) alkyl； Ar4 is selected from unsubstituted or substituted aryl and unsubstituted or substituted heteroaryl； R5 is selected from - (alkylene (C1-C6)) - NR5a2 and - (alkylene (C1-C6)) - NR5aC (>； = NR5a) NR5a2； each R5a is independently selected from hydrogen and (C1-C6) alkyl； Q is selected from the groups Q1, Q2, Q3 and Q4: ** Formula ** a and b represent the bonds that link Q to the rest of the molecule； R6 is selected from hydrogen, (C1-C6) alkyl and -C (>； = NR6a) NR6a2； each R6a is hydrogen or (C1-C6) alkyl； R7 is selected from (C1-C6) alkyl, unsubstituted aryl, substituted aryl, unsubstituted cycloalkyl and substituted cycloalkyl； R8 is selected fro
