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CARBOXYLIC ACID COMPOUND
专利权人:
ASTELLAS PHARMA INC.
发明人:
NEGORO, KENJI,OHNUKI, KEI,YONETOKU, YASUHIRO,KURAMOTO, KAZUYUKI,URANO, YASUHARU,WATANABE, HIDEYUKI
申请号:
EP10767073
公开号:
EP2423176A4
申请日:
2010.04.21
申请国别(地区):
EP
年份:
2012
代理人:
摘要:
[Problem] The present invention has an object to provide a compound having a GPR40 agonistic activity, which is useful as a pharmaceutical composition, an insulin secretion promoter, or an agent for preventing/treating diabetes. [Means for Solution] The present inventors have extensively studied a compound having a GPR40 agonistic activity, and as a result, they have found that the compound (I) of the present invention or a pharmaceutically acceptable salt thereof, in which a carboxylic acid is bonded to a bicyclic or tricyclic moiety through methylene, and further, a benzene ring substituted with a monocyclic 6-membered aromatic ring is bonded to a bicyclic or tricyclic moiety through -O-methylene or -NH-methylene, has an excellent GPR40 agonistic activity. They have also found that the compound has an excellent insulin secretion promoting action and strongly inhibits increase in the blood glucose after glucose loading, thereby completing the present invention.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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