THE UNIVERSITY OF TEXAS SYSTEM;THE BOARD OF REGENTS
发明人:
Eric N. Olson,Eva van Rooij
申请号：
US16509365
公开号：
US20200190511A1
申请日:
2019.07.11
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention relates to the identification of a microRNA family, designated miR-29a-c, that is a key regulator of fibrosis in cardiac tissue. The inventors show that members of the miR-29 family are down-regulated in the heart tissue in response to stress, and are up-regulated in heart tissue of mice that are resistant to both stress and fibrosis. Also provided are methods of modulating expression and activity of the miR-29 family of miRNAs as a treatment for fibrotic disease, including cardiac hypertrophy, skeletal muscle fibrosis other fibrosis related diseases and collagen loss-related disease.
