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Micro-RNA family that Modulates Fibrosis and Uses Thereof
专利权人:
The University of Texas System;The Board of Regents
发明人:
Eric N. Olson,Eva van Rooij
申请号:
US13840823
公开号:
US20130195891A1
申请日:
2013.03.15
申请国别(地区):
US
年份:
2013
代理人:
摘要:
The present invention relates to the identification of a microRNA family, designated miR-29a-c, that is a key regulator of fibrosis in cardiac tissue. The inventors show that members of the miR-29 family are down-regulated in the heart tissue in response to stress, and are up-regulated in heart tissue of mice that are resistant to both stress and fibrosis. Also provided are methods of modulating expression and activity of the miR-29 family of miRNAs as a treatment for fibrotic disease, including cardiac hypertrophy, skeletal muscle fibrosis other fibrosis related diseases and collagen loss-related disease.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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