The University of Texas System;The Board of Regents
发明人:
Eric N. Olson,Eva van Rooij
申请号：
US13840896
公开号：
US20130259908A1
申请日:
2013.03.15
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention relates to the identification of a microRNA family, designated miR-29a-c, that is a key regulator of fibrosis in cardiac tissue. The inventors show that members of the miR-29 family are down-regulated in the heart tissue in response to stress, and are up-regulated in heart tissue of mice that are resistant to both stress and fibrosis. Also provided are methods of modulating expression and activity of the miR-29 family of miRNAs as a treatment for fibrotic disease, including cardiac hypertrophy, skeletal muscle fibrosis other fibrosis related diseases and collagen loss-related disease.
