Liming Shao,Fengjiang Wang,Scott Christopher Malcolm,Michael Charles Hewitt,Jianguo Ma,Seth Ribe,Mark A. Varney,Una Campbell,Sharon Rae Engel,Larry Wendell Hardy,Patrick Koch,Rudy Schreiber,Kerry L. S
申请号：
US12131845
公开号：
US08669291B2
申请日:
2008.06.02
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Phenyl-substituted cyclohexylamine derivatives and method for their synthesis and characterization are disclosed. Use of these compounds to treat/prevent neurological disorders as well as methods for their synthesis are set forth herein. Exemplary compounds of the invention inhibit reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine (e.g., from the synaptic cleft) and modulate one or more monoamine transporter. Pharmaceutical formulations incorporating compounds of the invention are also provided.
