GlaxoSmithKline Intellectual Property Development Limited
发明人:
DAVIDSON, ALAN HORNSBY,DRUMMOND, ALAN HASTINGS,NEEDHAM, LINDSEY ANN
申请号：
PL06727008
公开号：
PL1877098T3
申请日:
2006.05.04
申请国别(地区):
PL
年份:
2013
代理人:
摘要：
Covalent conjugation of an alpha amino acid ester to a modulator of the activity of a target intr acellular enzyme or receptor, wherein the ester group of the conjugate is hydrolysable by intracellular carboxylesterase enzyme hCE1 and not by hCE2 or hCE3 to the corresponding acid, leads to selective accumulation of the carboxylic acid hydrolysis product in monocyte/macrophage cell and enables improved or more prolonged enzyme or receptor modulation in those cells relative to the unconjugated modulator.
