DRUMMOND, ALAN HASTINGS,DAVIDSON, ALAN HORNSBY,MOFFAT, DAVID FESTUS CHARLES,DONALD, ALISTAIR DAVID GRAHAM,DAVIES, STEPHEN JOHN
申请号：
CA2717020
公开号：
CA2717020C
申请日:
2009.02.27
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
Covalent conjugates of an .alpha.,.alpha.-disubstituted glycine ester and amodulator of the activity of a target intracellularenzyme or receptor, wherein the ester group of the conjugate is hydrolysableby one or more intracellular carboxylesterase enzymesto the corresponding acid and the .alpha.,.alpha.-disubstituted glycine esteris conjugated to the modulator at a position remote from thebinding interface between the inhibitor and the target enzyme or receptor passinto cells and the active acid hydrolysis productaccumulates within the cells.
