多靶向融合蛋白及其應用农业专利-农业学术服务平台

发明人:: ZEN, KEVIN,曾国辉,曾國輝,WU, PEI TZU,吴佩姿,吳佩姿,HER, JENG HORNG,何正宏,CHEN, HUANG TSU,陈皇慈,陳皇慈,LEOU, JIUN SHYANG,柳钧翔,柳鈞翔,HSU, CHING HSUAN,徐静轩,徐靜軒

摘要：: Fusion proteins containing a PDGF binding portion, a VEGF binding portion, and an Fc antibody region are described. Also described are nucleic acids encoding the fusion proteins, compositions comprising the fusion proteins, and methods of using the fusion proteins for treating or preventing clinical conditions characterized by abnormal angiogenesis, such as vascular permeability, edema or inflammation.本發明係關於融合蛋白，其係含有PDGF結合部分(binding portion)、VEGF結合部分、及Fc抗體區。本發明亦關於編碼該融合蛋白之核酸、包含該融合蛋白之組合物、及使用該融合蛋白以治療或預防臨床症狀之方法，該臨床症狀之特徵在於異常的血管生成，例如血管滲透性、水腫、或發炎。