A fishing hook is plated with, coated with, or contains an antimicrobial substance to treat the impalement wound of a fish caused by the hook. Specifically the hook includes at least one shank; at least one bend that extends from the shank; at least one point defined by a free end of the bend, wherein the fish hook contains a substance whose purpose is to minimize infection and to treat the puncture wound of a fish that is caught. The substance optionally acts to sterilize the hook to reduce the entrance of microbes into the wound when the puncture occurs. The substance may also contain an anti-inflammatory or a pain reliever to reduce the suffering of the fish or of others accidentally injured by the hook.