A new method for the treatment of ocular disease and injury are provided.The methods involve the administration of a biocompatible implant, the porcine small intestinal serosa (or serous membrane), as graft/patch directly to the eye, for inducing restoration, remodeling, and repair of a tissue in a variety of injuries or conditions in the cornea, conjunctiva, and/or the eyelid due to trauma, diseases, or surgery.A focus on graft interactions, safety profile has been fully defined and the membrane is reasonable in process, easy and convenient to prepare and significant in therapeutic effect.A simple standardized and straightforward method it has been developed to fabricate this ultra-thin, delicate, and transparent material.Derived from well-defined mechanical strength, the graft demonstrates consistency and flexibility than provides agile solutions for the Physician.