A COMPOUND REPRESENTED BY THE FOLLOWING FORMULA (I), OR SALT THEREOF EXHIBITS EXCELLENT CRF RECEPTOR ANTAGONISM, AND SUFFICIENT PHARMACOLOGICAL ACTIVITY, SAFETY AND PHARMACOKINETIC PROPERTIES AS A DRUG. WHEREIN R1 REPRESENTS THE FORMULA –A11-A12； R2 REPRESENTS TETRAHYDROFURYLMETHYL, TETRAHYDROPYRANYLMETHYL OR TETRAHYDROPYRANYL； A11 REPRESENTS A SINGLE BOND, METHYLENE OR 1,2-ETHYLENE； A12 REPRESENTS C1-6 ALKYL, C3-6 CYCLOALKYL OR C3-6 CYCLOALKYL HAVING METHYL； R3 REPRESENTS METHOXY, CYANO, CYCLOBUTYLOXYMETHYL, METHOXYMETHYL OR ETHOXYMETHYL； AND R4 REPRESENTS METHOXY OR CHLORINE.
