Metal Complexes with Bisphosphonate or Pyrophosphate Useful as Imaging Agents

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专利权人:

Duke University

发明人:

Lascola Christopher David

申请号：

US201715463688

公开号：

US2017189562(A1)

申请日:

2017.03.20

申请国别(地区):

美国

年份:

2017

代理人:

摘要：

Provided herein are magnetic resonance imaging (MRI) contrast agents comprising a compound having a structure represented by: Y—X—Z, wherein, X is: Fe(III) or Mn(II), and Y and Z are each independently selected from pyrophosphate and bisphosphonate (e.g., 1-hydroxybisphosphonate), or a pharmaceutically acceptable hydrate and/or salt thereof. Methods of use of the MRI contrast agent are also provided.

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