An object of the present invention is to provide a monoclonal antibody binding to human XCR1, wherein the antibody binds to linear or discontinuous epitopes which comprise at least three amino acids selected from the group consisting of the 8th, 11th, 12th, 13th, 14th, 16th, 17th, 22nd, 23rd, 176th, and 177th amino acids in the amino acid sequence of SEQ ID NO: 91.本發明的目的係提供一結合人類XCR1的單克隆抗體,其中該抗體結合包括選自下組的至少三個胺基酸的線性表位或非連續表位,該組由以下各項組成:SEQ ID NO:91的胺基酸序列中的第8、第11、第12、第13、第14、第16、第17、第22、第23、第176、和第177個胺基酸。