COMPOSÉ DÉRIVÉ DE PYRROLO-PYRIMIDINE, SON PROCÉDÉ DE PRÉPARATION, ET COMPOSITION PHARMACEUTIQUE COMPRENANT LEDIT COMPOSÉ EN TANT QUE PRINCIPE ACTIF POUR LA PRÉVENTION OU LE TRAITEMENT D'UNE MALADIE LIÉE À LA PROTÉINE KINASE
National Cancer Center;Samsung Life Public Welfare Foundation;Daegu-Gyeongbuk Medical Innovation Foundation
发明人:
申请号：
EP18757481.9
公开号：
EP3587422A4
申请日:
2018.02.22
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
The present invention relates to a novel pyrrolo-pyrimidine derivative compound, a preparation method therefor, and a pharmaceutical composition comprising the same compound as an effective ingredient for preventing or treating a protein kinase-related disease. The compound represented by Chemical Formula 1 according to the present invention, an optical isomer thereof, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same as an effective ingredient has outstanding inhibitory activity against LRRK2 kinase and against phosphorylation in the NIH-3T3 cell line, which is an LRRK2-expressing cell line, and NCC01 and 448T cell lines, which are both derived from patients with brain tumors. Verified to have inhibitory activity against various protein kinases in addition to LRRK2, the compound can find effective applications in the treatment or prevention of protein kinase-related diseases.
