PROBLEM TO BE SOLVED: To provide a new compound having a cannabinoid receptor agonistic activity and useful as a treating agent of atopic dermatitis and an anti-itching agent, and a medicinal composition containing the compound.SOLUTION: This compound is expressed by general formula (I) [wherein, R1 is a 1-8C alkyl or the like R2 is a 1-6C alkyl R3 is a 1-6C alkyl or the like, or R2 and R3 may together form a 5-10-membered non-aromatic ring R4 is a hydrogen atom or the like and G is formula (&alpha) (wherein R5 is a hydrogen atom or the like X1 is a single bond or the like X2 is a 1-8C alkylene which may be intervened by -O-, or the like and X3 is a single bond or the like)]. The medicinal composition containing the compound is also provided.COPYRIGHT: (C)2008,JPO&INPIT【課題】カンナビノイド受容体アゴニスト作用を有し、アトピー性皮膚炎治療剤、抗掻痒剤として有用な新規化合物、及び該化合物を含有する医薬組成物の提供。【解決手段】一般式(I)式中、R1はC1-C8アルキル等;R2はC1-C6アルキル;R3はC1-C6アルキル等;又はR2及びR3は一緒になって5~10員の非芳香族炭素環を形成してもよい;R4は水素原子等;Gは式:(式中、R5は水素原子等;X1は単結合等;X2は-O-などを介在していてもよいC1-C8アルキレン等;X3は単結合等)で示される化合物、及び該化合物を含有する医薬組成物。【選択図】なし
