KIM, DONG YEON,CHO, DAE JIN,LEE, GONG YEAL,KIM, HONG YOUB,WOO, SEOK HUN,LEE, HAE UN,AHN, CHOONG AM,YOON, SEUNG BIN
申请号：
PE0020022013
公开号：
PE06292014A1
申请日:
2012.03.30
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
Refers to phenyl isoxazole derivative compounds of formula (1) wherein R1, R2 and R3 are each h, halogen, alkoxy optionally substituted Lower alkyl or lower Halogen R4 is Methyl or Amine R8 is a compound with Formula 2 or 3, wherein R5, R6 and R7 are each H Lower alkyl, Halogen, Hydroxy, among others R9 is lower alkyl.Preferred compounds are: (4 - (3-methoxyphenyl) piperazine (IL - 1 - 5 - methyl) - 3 - (2 - (trifluoromethyl) phenyl isoxazole) - 4-yl) methanone (4 - (2-fluorophenyl) - piperazine 1 - 5 (IL) - 3 - (2 - methyl - (trifluoromethyl) phenyl) methanone isoxazole) il - 4 - (4 - (3,4-dichlorophenyl) piperazine (IL - 1 - 5 - methyl) - 3 - (2 - (trifluoromethyl) phenyl) - 4 - isoxazole IL) methanone among others.It also relates to a preparation method and a Pharmaceutical composition. These compounds inhibit the activity of influenza virusSE REFIERE A COMPUESTOS DERIVADOS DE FENIL-ISOXAZOL DE FORMULA (1) DONDE R1, R2 Y R3 SON CADA UNO H, HALOGENO, ALQUILO INFERIOR O ALCOXI INFERIOR OPCIONALMENTE SUSTITUIDOS CON HALOGENO R4 ES METILO O AMINA R8 ES UN COMPUESTO DE FORMULA 2 O 3, EN DONDE R5, R6 Y R7 SON CADA UNO H, ALQUILO INFERIOR, HIDROXI, HALOGENO, ENTRE OTROS R9 ES ALQUILO INFERIOR. SON COMPUESTOS PREFERIDOS: (4-(3-METOXIFENIL)PIPERAZINA-1-IL)(5-METIL-3-(2-(TRIFLUOROMETIL)FENIL)ISOXAZOL-4-IL)METANONA (4-(2-FLUOROFENIL)PIPERAZINA-1-IL)(5-METIL-3-(2-(TRIFLUOROMETIL)FENIL)ISOXAZOL-4-IL)METANONA (4-(3,4-DICLOROFENIL)PIPERAZINA-1-IL)(5-METIL-3-(2-(TRIFLUOROMETIL)FENIL)ISOXAZOL-4-IL)METANONA ENTRE OTROS. TAMBIEN SE REFIERE A UN METODO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS INHIBEN LA ACTIVIDAD DEL VIRUS DE LA INFLUENZA
