ZHANG, JIAZHONG,BREMER, RYAN,SPEVAK, WAYNE,CHO, HANNA,IBRAHIM, PRABHA N.
申请号：
PE0006172012
公开号：
PE13272012A1
申请日:
2010.11.04
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
Refers to compounds derived from pirrolo [2,3-b] pyridin-3 of formula (i) wherein R1, R2, R3 and R4 are each h, halogen, Lower alkyl, cicloalquilamino, among others R5 is H, F, CL, Lower alkyl, pirazolilo, CN, among others R6 h, halogen pirazolilo, cycloalkyl, phenyl, among others Ar is a compound of formula (i), (ii), (iii), among others, where R7 is HHalogen or lower alkyl or Halogen R9 is H.Preferred compounds are: [5 - (5 - Chloro - 1H pyrrolo [2,3-b] pyridin - 3 - ylmethyl) pyridin-2-yl] - (2,6 - Dimethoxy - pyridin - 3 - methyl) Amine n - (3 - [6 - [(6 - Chloro - pyridin - 3 - methyl) amino] - 2 - fluoro - pyridin - 3 - methyl) - 1H pyrrolo [2,3-b] pyridin - 5 - il) methanesulfonamide n - (3 - {[2 - (4-fluoro-6 - 5 - fluoro - pyridin 2 - methoxy - 3 - I Lmetil) - amino] - pyridin - 3 - methyl) - 1H pyrrolo [2,3-b] pyridin - 5 - il) - acetamide among others.It also relates to a Pharmaceutical composition. These compounds are inhibitors of kinases FMS, Kit and flt-3 being useful in the treatment of Multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, lupus glomerulonephritisSE REFIERE A COMPUESTOS DERIVADOS DE PIRROLO[2,3-b]PIRIDIN DE FORMULA (I) DONDE R1, R2, R3 Y R4 SON CADA UNO H, HALOGENO, ALQUILO INFERIOR, CICLOALQUILAMINO, ENTRE OTROS R5 ES H, F, Cl, ALQUILO INFERIOR, PIRAZOLILO, CN, ENTRE OTROS R6 ES H, HALOGENO, CICLOALQUILO, FENILO, PIRAZOLILO, ENTRE OTROS Ar ES UN COMPUESTO DE FORMULA (i), (ii), (iii), ENTRE OTROS, EN DONDE R7 ES H, HALOGENO O ALQUILO INFERIOR R9 ES H O HALOGENO. SON COMPUESTOS PREFERIDOS: [5-(5-CLORO-1H-PIRROLO[2,3-b]PIRIDIN-3-ILMETIL)-PIRIDIN-2-IL]-(2,6-DIMETOXI-PIRIDIN-3-ILMETIL)-AMINA N-(3-{6-[(6-CLORO-PIRIDIN-3-ILMETIL)-AMINO]-2-FLUORO-PIRIDIN-3-ILMETIL}-1H-PIRROLO[2,3-b]PIRIDIN-5-IL)-METANOSULFONAMIDA N-(3-{2-FLUORO-6-[(5-FLUORO-2-METOXI-PIRIDIN-3-ILMETIL)-AMINO]-PIRIDIN-3-ILMETIL}-1H-PIRROLO[2,3-b]PIRIDIN-5-IL)-ACETAMIDA ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHI
