A device for guiding a medical imaging probe in order to move the probe close to an anatomical space, the probe having a mechanism for acquiring images of the anatomical space, and the device having at least one sensor mounted to the probe. The device includes a processing mechanism for deducing a rotation of the probe in the space from the signals generated by the sensor and for estimating a plurality of plausible positions of the probe relative to the anatomical space by deducing the rotation of the probe in the space. The processing mechanism is arranged such as to determine the position of the probe relative to the anatomical space from the plausible positions. Also disclosed is a method for guiding the probe.