Sanford Burnham Prebys Medical Discovery Institute
发明人:
Takuya IKEDA,Yoshiyuki KOBAYASHI,Naoki MIYOSHI,Osamu SUZUKI,Takahiro NAGAYAMA,Takashi TSUJI,Layton H. SMITH,Anthony B. PINKERTON
申请号：
US15778168
公开号：
US20180282289A1
申请日:
2016.11.21
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to a novel azole derivative as an apelin receptor agonist and a method for treating cardiovascular disease, diabetic disease, renal disease, hypertension, and arteriosclerosis, etc., using the same. The present invention provides a compound represented by formula (I) or a pharmacologically acceptable salt thereof wherein X1 represents —NH═ or —CH═, X2 represents —CH═ or —N═, R1 and R2 each represent a C1 to C6 alkoxy group or the like, R3 represents a heteroaryl group (the heteroaryl group is optionally substituted by a methyl group or the like) or the like, and R4 represents a C1 to C6 alkylthio group or a C2 to C6 alkenyl group (the C1 to C6 alkylthio group and the C2 to C6 alkenyl group are each optionally substituted by one carboxy group or the like) or the like.
