Se proporcionan prof rmacos de nucle sidos fosfato de pirrolo 1 2-f 1 2 4 triazin-7-ilo en donde la posici n 1 26rsquo del az car del nucle sido est sustituida con CN Los compuestos las composiciones y los usos provistos son eficaces para N (R4) 2, SR4, C2-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, C3-8 carbocyclyl, C4-8 carbocyclyl alkyl, aryl-C1-8 alkyl, heterocyclyl-C1-8 alkyl, aryl, heterocyclyl or heteroaryl； each Ra, R4 or R6 is independent of C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, C3-8 carbocyclyl, C4-8 carbocyclyl alkyl, aryl-C1-8 alkyl, heterocyclyl-C1-8 alkyl, C6 aryl -20, C2-20 heterocyclyl or heteroaryl； one of the W1 or W2 is a compound of formula (2) and the other of W1 or W2 is OR4 or the compound of formula (2)；each Rc, Rd or R5 is independent of H, C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, C3-8 carbocyclyl, C4-8 carbocyclyl alkyl, aryl-C1-8 alkyl, heterocyclyl-C1-8 alkyl alkyl, C6-20 aryl, C2-20 heterocyclyl or heteroaryl； Each R8 is a halogen, NR11R12, N (R11) OR11, NR11NR11R12, N3, NO, NO2, CHO, CN, -CH (= NR11),CH 3DNNHR11 CH 3DN (OR11)CH (OR11) 2 C (3DO) NR11R12 C (3DS) NR11R12 C (3DO) OR11 alquilo C1-8 alquenilo C2-8 alquinilo C2-8 carbociclilalquilo C4-8 arilo C6-20 heterociclilo C2-20 heteroarilo -C (3DO) -CH 3DNHNR11 -CH 3DN (OR11)-From heterosexual to 21, and from various perspectives, or from the following different types of people to 20-20 (C6) or from different types of people, or from different c6c1-8 -S (o) c1-8 or R11 and R12 tar together with the nitrogen connected with them form a heterocyclic ring composed of 3 to 7 members. In this heterocyclic ring structure, any carbon atom can be - or--S (O) n- o -NRa-wherein each C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, C3-8 carbocyclyl, C4-8 carbocyclyl alkyl, aryl-C1-8 alkyl, heterocyclyl-C1-8 alkyl, C6-20 aryl, C2- heterocyclyl 20, heteroaryl of Rc, Rd, R1, R2, R3, R4, R5, R6, R8, R11 or R12 is,Independently and selectively substituted with one or more halides, hydroxyls, CN, N3, n (RA) 2nh (RA),NH
