Liquid polymer pharmaceutical compositions with a biodegradable liquid polyester that has a carboxylic acid end group, a biocompatible solvent, and an active pharmaceutical agent are useful for administration into the body to provide extended long term release of the drug.本發明提供液態聚合物醫藥組合物,其具有具羧酸端基之生物可降解液態聚酯、生物相容性溶劑及活性藥劑,其適用於投入身體中以提供藥物之延長的長期釋放。