PROBLEM TO BE SOLVED: To provide a method for inhibiting protein denaturation for decreasing a denaturation degree of protein having a molecular weight of 75,000 to 1,000,000 even after long-term storage.SOLUTION: The method aims to inhibit denaturation of a component (2) caused by reducing sugar in a composition containing reducing sugar and the following components (1) and (2). The components are: (1) at least one kind in amino acids, peptides and proteins having a molecular weight of 75 to 68,000 and (2) a protein having a molecular weight of 75,000 to 1,000,000. In the method, the content of the component (2) in the composition is controlled to 0.75 to 10 wt.% and the whole amount of the component (1) is controlled to 20 to 50 moles with respect to one mole of the component (2).COPYRIGHT: (C)2012,JPO&INPIT【課題】長期保存後であっても分子量75000~1000000のタンパク質の変性の程度を少なくする、タンパク質変性抑制方法を提供すること。【解決手段】本発明は、還元糖、並びに下記成分(1)及び(2)を含有する組成物における還元糖による成分(2)の変性を抑制する方法であって、当該組成物中の成分(2)の含有量を0.75~10重量%とし、かつ成分(2)1モルに対する成分(1)の総量を20~50モルとする、方法を提供する:(1)分子量75~68000のアミノ酸、ペプチド及びタンパク質の少なくとも一種(2)分子量75000~1000000のタンパク質。【選択図】なし
