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bicyclic compounds useful for treating retrovirus diseases
专利权人:
INSTITUT CURIE;ABIVAX;UNIVERSITE DE MONTPELLIER;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
发明人:
AUDE GARCEL,DIDIER SCHERRER,FLORENCE MAHUTEAU-BETZER,JAMAL TAZI,NOËLIE CAMPOS,ROMAIN NAJMAN
申请号:
BR112016000127
公开号:
BR112016000127A8
申请日:
2014.07.04
申请国别(地区):
BR
年份:
2018
代理人:
摘要:
1/1 summary "Bicyclic compounds useful for treating retroviral disease" are described herein methods for preventing or treating retroviral infection and / or for preventing, inhibiting or treating a disease caused by retroviral infection. in certain aspects, the methods described herein include contacting a cell in need thereof with compound (i) wherein (ii) means a pyridazine, a pyrimidine or a pyrazine group, independently represents a hydrogen atom, a halogen atom or a group chosen from a -cn group, a hydroxyl group, a -coor1 group, a (C1-C3) fluoroalkyl group, a (C1-C3) fluoroalkoxy group, a -no2 group, a -nr1r2 group, an alkoxy group (C 1 -C 4), a phenoxy group and a (C 1 -C 3) alkyl group, said alkyl being optionally monosubstituted by a hydroxyl group, n is 1, 2 or 3, n 'is 1 or 2, r' is an atom hydrogen, a halogen atom or a group selected from a (C1-C3) alkyl group, a hydroxyl group, a -coor1 group, a -no2 group, a -nr1r2 group, a morpholinyl group or a morpholino group n-methylpiperazinyl, a (C1-C3) fluoroalkyl group, a (C1-C4) alkoxy group and a group -cn, z is n or c, y is n or c, x is n or c, w is n or c, t is n or c, u is n or c, to prevent or treat retroviral infection and / or to prevent, inhibit or treat a disease caused by retroviral infection, where the retroviral infection is not hiv and the disease caused by the infection. retroviral is not AIDS.1/1 resumo “compostos bicíclicos úteis para tratar doenças causadas por retrovírus” são aqui descritos métodos para prevenir ou tratar uma infecção retroviral e/ou para prevenir, inibir ou tratar uma doença causada pela infecção retroviral. em certos aspectos, os métodos aqui descritos incluem contatar uma célula em necessidade dos mesmos com o composto (i) em que (ii) significa um grupo piridazina, um pirimidina ou um pirazina, r independentemente representa um átomo de hidrogênio, um átomo de halógeno ou um grupo escolhido entre um grupo -cn, um grupo hidroxila, um grupo -coor1, um grupo fluoroalquila (
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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