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nanoemulsion and method,
专利权人:
UNIVERSITY OF MASSACHUSETTS LOWELL
发明人:
Robert Nicolosi,Thomas Wilson
申请号:
BRPI0613631
公开号:
BRPI0613631A8
申请日:
2006.07.11
申请国别(地区):
BR
年份:
2017
代理人:
摘要:
Nanoemulsion, Method, and Use of a Compound and Nanoemulsion The present invention provides an improved nanoemulsion composed of a uniform and distinct range of very small nano size particle diameters. This uniformity results in improved bioavailability of the incorporated (i.e., pharmaceutical or nutraceutical) compounds as reflected in various pharmacokinetic parameters, including, but not limited to, reduced tmax, increased cmax, and increased auc. The improved method of producing these uniform nanoemulsions utilizes microfluidization, which is different in both process and mechanics compared to the conventional grinding and grinding techniques used to generate nanoparticle compositions. furthermore, the improvement results in part from a new step of mixing a substantially soluble compound in a heated dispersion medium. This is different from current nanoparticle composition methods that mix an insoluble compound with an unheated dispersion medium. In addition, these nanoemulsions have been found to be resistant to bacteria and stable at extremes of both temperature and pil changes. therefore, these nanoemulsions are expected to have a significantly longer shelf life than currently available nanoemulsions.nanoemulsão, metodo, e, uso de um composto e de uma nanoemulsão a presente invenção apresenta uma nanoemulsão melhorada composta de uma faixa uniforme e distinta de diâmetros de partículas muito pequenas com tamanho nano. esta uniformidade resulta em uma biodisponibilidade melhorada dos compostos incorporados (i.e., farmacêuticos ou nutracêuticos) conforme refletido em vários parâmetros fármaco-cinéticos, incluindo, mas não limitados a, tmax reduzida, cmax aumentada, e auc aumentada. o método melhorado de produção destas nanoemulsões uniformes utiliza microfluidização, que é diferente, tanto no processo como na mecânica, quando comparado com as técnicas convencionais de moagem e trituração usadas para gerar composições de nanopartículas. além disso, a melhoria r
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