The present disclosure relates to a composition including non-autologous plasma or serum and a polymer method of treating ophthalmic diseases (e.g., dry eye syndrome) or moisturizing and/or repairing non-keratinized surfaces including non¬ healing wounds with a composition including non-autologous plasma or serum and a polymer and a therapeutic agent delivery device for delivery of the composition to the eye or a non-keratinized surface of a subject.