WINTERS, GEOFFREY C.,RICH, JAMES R.,GARNETT, GRAHAM ALBERT EDWIN,MANDEL, ALEXANDER LAURENCE,HSIEH, TOM HAN HSIAO,BOURQUE, ELYSE MARIE JOSEE,BARNSCHER, STUART DANIEL
申请号：
CA2960899
公开号：
CA2960899A1
申请日:
2015.09.17
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.
