CHILDREN'S HOSPITAL MEDICAL CENTER;GARDNER, PAUL, R.
发明人:
GARDNER, PAUL, R.
申请号：
WO2005US18464
公开号：
WO2005117545(A3)
申请日:
2005.05.26
申请国别(地区):
世界知识产权组织国际局
年份:
2007
代理人:
摘要：
A method and composition to inhibit the enzyme nitric oxide dioxygenase (NOD) and therefore accumulate nitric oxide (NO) in cells or tissues. By preventing NO removal, the inhibitors may effect cellular signaling, modulate vasotension, enhance O<SUB>2</SUB> delivery to tissues, and provide antibiotic and/or antineoplastic effects. Inhibitors include compounds that bind to the iron in the heme portion of NOD, and include allicin and azotes.
