Jason Richard Betley,James Christopher Pearson,Ben Martin Beacom,Tadeusz Antoni Podgorski,Robert William Pannell
申请号：
US11913528
公开号：
US08551994B2
申请日:
2006.05.09
申请国别(地区):
US
年份:
2013
代理人:
摘要：
For the separation, removal, isolation, purification, characterization, identification or quantification of fibrinogen or a protein that is a fibrinogen analogue, an affinity adsorbent is used that is a compound of formula II wherein one X is N and the other is N, C—Cl or C—CN Y is O, S or NR2 0 Z is O, S or NR3 R2 and R3 are each H, alkyl, hydroxyalkyl, benzyl or &bgr -phenylethyl n is 0 to 6 A is a support matrix, optionally linked to the triazine ring by a spacer R7 is a group bearing a positive charge at neutral pH W is an optional linker V is an aromatic group and R8 and R9 are each H, OH, alkyl, alkoxy, amino, NH2, acyloxy, acylamino, CO2H, sulphonic acid, carbamoyl, sulphamoyl, alkylsulphonyl or halogen or a cyclic structure such as a morpholino group, or R8 and R9 are linked to form such a cyclic structure.
