Jason Richard Betley,James Christopher Pearson,Ben Martin Beacom,Tadeusz Antoni Podgorski,Robert William Pannell
申请号：
US13954237
公开号：
US09221768B2
申请日:
2013.07.30
申请国别(地区):
US
年份:
2015
代理人:
摘要：
For the separation, removal, isolation, purification, characterisation, identification or quantification of fibrinogen or a protein that is a fibrinogen analogue, an affinity adsorbent is used that is a compound of formula IIwherein one X is N and the other is N, C—CI or C—CNY is O, S or NR2Z is O, S or NR3R2 and R3 are each H, alkyl, hydroxyalkyl, benzyl or β-phenylethyl n is 0 to 6A is a support matrix, optionally linked to the triazine ring by a spacerR7 is a group bearing a positive charge at neutral pHW is an optional linkerV is an aromatic group andR8 and R9 are each H, OH, alkyl, alkoxy, amino, NH2, acyloxy, acylamino, CO2H, sulphonic acid, carbamoyl, sulphamoyl, alkylsulphonyl or halogen or a cyclic structure such as a morpholino group, or R8 and R9 are linked to form such a cyclic structure.
