It regards the formulation, and its use which are obtained from the chemical structure and the said structure which are obtained by the application of method, and the said method of obtaining the antigenic structure where as for this invention, systemic characteristic and/or it can reinforce the immuneresponse for the cohesion antigen which is prescribed with mucous membrane route it is possible coheres at the same time to form powerful immuneresponse.To discharge the lipid from the particle and its various cohesion ones it is possible this method, using cohesion characteristic, removal of fat characteristic or the oxidation characteristic substance or chemical compound, being the method of obtaining the new antigenic structure which coheres, cohesion ones which possess the grain size 30 - 500nm next, are selected by molecular removal process, the above-mentioned method is stated. It is possible to induce cohesion state in the yeast by modifying inkiyubeshiyon condition. The structure which it occurs adds the adjuvant, or can use for convenience in the formulation which can introduce several antigens in regard to the immunogenicity of the response which is obtained, the multiplier action between the component can see. In addition as for any this manufacturing things, as for the antigenic structure which is possible to contain stability and the retention medicine, occurs, in medical supply industry, with use to the person and the animal, is possible the fact that you use and as portion of the diagnostic system for prevention or as the vaccine formulation for remedy.本発明は、全身性および/または粘膜経路で投与される凝集抗原に対する免疫応答を増強することができ、かつ強力な免疫応答を生成することができる、凝集した抗原性構造体を得る方法、および該方法の応用により得られる化学的構造体、該構造体から得られる製剤、およびその使用に関する。本方法は、粒子およびその異種凝集物から脂質を放出することができる、凝集性、脱脂性もしくは酸化性の物質または化合物を使用して、新規の凝集した抗原性構造体を得る方法であって、次に30~500nmの粒子サイズを有する凝集物が、分子排除プロセスにより選択される、上記方法を記載する。インキュベーション条件を変更することにより、酵母中に凝集状態を誘導することができる。生じる構造体は、アジュバントを加えるかまたはいくつかの抗原が導入できる製剤中で便利に使用することができ、得られる応答の免疫原性に関して、成分間の相乗作用が見られる。この調製物はまた、安定性および
