Allison Anne Byers Horner;Rosemary Girgis;Dina Rebecca McLain;Zhiyong Ding;Harald Junge;Katherin E. Combs;Ling Ling Culbertson;Erin Marie Massey;Frederic de Sauvage;Joel Edwards;Jagath Reddy Junutula
发明人:
Katherin E. Combs,Ling Ling Culbertson,Frederic de Sauvage,Zhiyong Ding,Joel Edwards,Rosemary Girgis,Allison Anne Byers Horner,Harald Junge,Jagath Reddy Junutula,Erin Marie Massey,Dina Rebecca McLain
申请号：
US12910746
公开号：
US20120030776A1
申请日:
2010.10.22
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO69122, PRO204, PRO214, PRO222, PRO234, PRO265, PRO309, PRO332, PRO342, PRO356, PRO540, PRO618, PRO944, PRO994, PRO1079, PRO1110, PRO1122, PRO1138, PRO1190, PRO1272, PRO1286, PRO1295, PRO1309, PRO1316, PRO1383, PRO1384, PRO1431, PRO1434, PRO1475, PRO1481, PRO1568, PRO1573, PRO1599, PRO1604, PRO1605, PRO1693, PRO1753, PRO1755, PRO1777, PRO1788, PRO1864, PRO1925, PRO1926, PRO3566, PRO4330, PRO4423, PRO36935, PRO4977, PRO4979, PRO4980, PRO4981, PRO5801, PRO5995, PRO6001, PRO6095, PRO6182, PRO7170, PRO7171, PRO7436, PRO9912, PRO9917, PRO37337, PRO37496, PRO19646, PRO21718, PRO19820, PRO21201, PRO20026, PRO20110, PRO23203 or PRO35250 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders； cardiovascular, endothelial or angiogenic disorders； eye abnormalities； immunological disorders； oncological disorders； bone metabolic abnormalities or disorders； lipid metabolic disorders； or developmental abnormalities.
