The toriputohuan derivative which makes the bone bud cell activate and the bone which uses this the pore symptom remedy, the bone bud cell activator is offered roughly. As for this invention, next formula (i):[Conversion 1](In formula, as for X displaying halogen atom As for R1 hydrogen atom, substitution or C1-6- alkyl group of non substitution, substitution or C2-6- arukeniru basis of non substitution, substitution or C2-6- arukiniru basis of non substitution, substitution or aromatic basis of non substitution, substitution or aralkyl basis of non substitution, substitution or acyl basis of non substitution, substitution or aryl sulfonyl basis of non substitution, substitution or C1-6- alkyl sulfonyl basis of non substitution, substitution or displaying C2-7- alkoxy carbonyl group, or hydroxyl group of non substitution As for R2 substitution or displaying C1-21- alkyl group of non substitution R3, R5 and R6 to differ equality or, displaying the hydrogen atom or the halogen atom As for R4 hydrogen atom, or substitution or displaying C1-6- alkyl group of non substitution R7 the hydrogen atom, or, substitution or displays C1-21- hydrocarbon radical of non substitution.)So the chemical compound which is shown or that salt, and the bone which contains these roughly it regards the pore symptom remedy and the bone bud cell activator.骨芽細胞を活性化させるトリプトファン誘導体及びこれを用いた骨粗鬆症治療薬、骨芽細胞活性化剤を提供する。本発明は、次式(I):[化1](式中、Xはハロゲン原子を表し;R1は水素原子、置換又は非置換のC1-6-アルキル基、置換又は非置換のC2-6-アルケニル基、置換又は非置換のC2-6-アルキニル基、置換又は非置換の芳香族基、置換又は非置換のアラルキル基、置換又は非置換のアシル基、置換又は非置換のアリールスルホニル基、置換又は非置換のC1-6-アルキルスルホニル基、置換又は非置換のC2-7-アルコキシカルボニル基、又は水酸基を表し;R2は置換又は非置換のC1-21-アルキル基を表し;R3、R5及びR6は、同一又は異なり、水素原子又はハロゲン原子を表し;R4は水素原子、又は置換又は非置換のC1-6-アルキル基を表し;R7は水素原子、又は、置換又は非置換のC1-21-炭化水素基を表す。)で示される化合物又はその塩、並びにこれらを含有する骨粗鬆症治療薬及び骨芽細胞活性化剤に関する。
