The present invention provides a highly pure N-protected L-carnosine derivative and a simple method for producing L-carnosine. A production method comprising reacting an acid halide (1) with an L-histidine derivative (2). (R1 and R2 are protecting groups for H or amino group； X represents a halogen atom) (TMS group represents a trimethylsilyl group) [Selection] None【課題】高純度のＮ－保護Ｌ－カルノシン誘導体、及びＬ－カルノシンの簡便な製造方法の提供。【解決手段】酸ハロゲン化物（１）と、Ｌ－ヒスチジン誘導体（２）とを反応させることを含む製造方法。（Ｒ１、Ｒ２は、Ｈ又はアミノ基の保護基；Ｘはハロゲン原子を表す）（ＴＭＳ基はトリメチルシリル基を表す）【選択図】なし
