The present invention provides a highly pure N-protected L-carnosine derivative and a simple method for producing L-carnosine. A production method comprising reacting an acid halide (1) with an L-histidine derivative (2). (R1 and R2 are protecting groups for H or amino group; X represents a halogen atom) (TMS group represents a trimethylsilyl group) [Selection] None【課題】高純度のN-保護L-カルノシン誘導体、及びL-カルノシンの簡便な製造方法の提供。【解決手段】酸ハロゲン化物(1)と、L-ヒスチジン誘導体(2)とを反応させることを含む製造方法。(R1、R2は、H又はアミノ基の保護基;Xはハロゲン原子を表す)(TMS基はトリメチルシリル基を表す)【選択図】なし