Axel BECKER,Clemens KUEHN,Christoph SAAL,Oliver SCHADT,Dieter DORSCH,Heinz-Hermann BOKEL,Frank STIEBER,Cristina DONINI
申请号：
US14609137
公开号：
US20150148351A1
申请日:
2015.01.29
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to 3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile hydrochloride solvates and crystalline modifications thereof. The present invention further relates to processes of manufacturing these crystalline modifications as well as their use in the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by the inhibition, regulation and/or modulation of signal transduction of kinases, in particular by the inhibition of tyrosine kinases, e.g. pathophysiological conditions such as cancer.
