As for this invention, the transplantation body of the bone - cartilage organization which possesses the structure where bone tissue and cartilage organization have been connected And, at least the cartilage formation sex cell of 1 where it is chosen from the group which consists of the trunk cell which at least can differentiate in the bone formation sex cell and the cartilage cell or the cartilage cell of 1 where it is chosen from the group which consists of the trunk cell which can differentiate in the osteoclast or the osteoclast kinds kinds, it regards the production method of the transplantation body of the bone - cartilage organization which includes the process which is seeded in the foothold material which can keep the cell when the bone formation sex cell and the cartilage formation sex cell have separated substantially.本発明は、骨組織と軟骨組織が繋がっている構造を有する骨-軟骨組織の移植体;および、骨細胞あるいは骨細胞に分化し得る幹細胞からなる群から選ばれる少なくとも1種の骨形成性細胞並びに軟骨細胞あるいは軟骨細胞に分化し得る幹細胞からなる群から選ばれる少なくとも1種の軟骨形成性細胞を、骨形成性細胞と軟骨形成性細胞が実質的に分離した状態で細胞を保持し得る足場材料に播種する工程を含む骨-軟骨組織の移植体の製造方法に関する。
