Human antibody against aggrecanase-type ADAMTS species for therapeutics of aggrecanase-related diseases

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专利权人:

Keio University;GeneFrontier Corporation

发明人:

Miyakoshi, Akira,Nakamura, Mikiko,Kojoh, Kanehisa,Mochizuki, Satsuki,Okada, Yasunori

申请号：

AU2014335251

公开号：

AU2014335251A1

申请日:

2014.10.14

申请国别(地区):

AU

年份:

2016

代理人:

摘要：

The present invention provides an antibody that specifically binds to human aggrecanase, and inhibits enzymatic activity of the human aggrecanase. In one embodiment, aggrecanase is ADAMTS4. In one embodiment, the antibody recognizes a particular epitope in human ADAMTS4, and inhibits not only aggrecanase activity of human ADAMTS4 but also aggrecanase activity of human ADAMTS5. In addition, the present invention also provides use of said antibody in the prophylaxis or treatment of the progression of arthritis.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/