Human antibodies against aggrecanase-type ADAMTS species for the treatment of aggrecanase-related diseases

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专利权人:

学校法人慶應義塾;ジーンフロンティア株式会社

发明人:

宮越 陽,中村 美紀子,古城 周久,望月 早月,岡田 保典

申请号：

JP2016524160

公开号：

JP6454893B2

申请日:

2014.10.14

申请国别(地区):

JP

年份:

2019

代理人:

摘要：

The present invention provides an antibody that specifically binds to human aggrecanase, and inhibits enzymatic activity of the human aggrecanase. In one embodiment, aggrecanase is ADAMTS4. In one embodiment, the antibody recognizes a particular epitope in human ADAMTS4, and inhibits not only aggrecanase activity of human ADAMTS4 but also aggrecanase activity of human ADAMTS5. In addition, the present invention also provides use of said antibody in the prophylaxis or treatment of the progression of arthritis.

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中国工程科技知识中心

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http://www.ckcest.cn/home/