Compound of formula (I) including any stereochemically isomeric form thereof, wherein n is an integer 1, 2 or 3； m is an integer 1, 2 or 3； p is an integer 1 or 2； R3 is hydrogen, halo, C1-4 alkyl or C1-4 alkyloxy； X represents O, S, SO2, CR4R5 or NR6； wherein R4 and R5 are each independently selected from each other from hydrogen, halo, hydroxyl, C1-4 alkyl, C1-4 alkyloxy or aryl； wherein R6 is hydrogen, phenyl, -CO-R7 or -CO-O-R7, wherein R7 is C1-6 alkyl or amino； R1 is a heterocycle selected from pyridinyl or pyrimidinyl, wherein said heterocycle is substituted with one or two substituents each independently selected from hydrogen, halo, hydroxyl, C1-6 alkyl, C1-6 alkyloxy, C1-4 polyhaloalkyl, phenyl, C3-6 cycloalkyl, C3-6 cycloalkyloxy, C3-6 cycloalkyl-C1-4 alkyloxy or NR8R9； wherein R8 and R9 are independently selected from each other from hydrogen, C1-6 alkyl, C1-6 hydroxyalkyl, C3-6 cycloalkyl, and wherein R8 and R9 can be taken together with the nitrogen atom to which they are attached to forming an azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl or morpholinyl ring which may be optionally substituted with one or two substituents each independently selected from each other from C 1-4 alkyl, C 1-4 alkyloxy, halo, hydroxyl or C 1-4 alkylcarbonyl； R2 is a heterocycle selected from quinolinyl or isoquinolinyl, wherein said heterocycle is substituted with one or two substituents each independently selected from hydrogen, halo, hydroxyl, C1-6 alkyl, C1-6 alkyloxy, C3-6 cycloalkyl, C1-6 cycloalkyloxy, C1-4 polyhaloalkyl, NR10R11 and OR12； wherein R10 and R11 are independently selected from each other from hydrogen, C1-6 alkyl, C3-6 cycloalkyl, C1-4 polyhaloalkyl, tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, N- (1,5-dioxa-9-azaspiro [5.5 ] undec-9-yl), N- (1, 7-diaza-spiro [4.4] non-7-yl), N- (2, 6-diaza-spiro [4.5] dec-2-yl) and C1-alkyl -6 substituted with one or two substituents selected from hydroxyl, halo, aryl1, C1-4 alkyloxy, C3-6 cycloalkyl, hydrox
