Sofia A. Casares,Teodor D. Brumeanu,Thomas L. Richie
申请号：
US13581483
公开号：
US09557323B2
申请日:
2011.09.26
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Provided is a transgenic animal model for testing immunogenicity and protective efficacy of human vaccines and the method for generating such a multitransgenic animal. Also disclosed are methods for screening compositions for human vaccine development. More specifically, a mouse model capable of expressing human leukocyte antigen DR4, and human costimulatory molecules (CD80) upon infusion of human HLA-matched hematopoietic stem cells, which can develop into a functional human immune system is provided.
