CaMKII, IP3R, calcineurin, p38 and MK2/3 inhibitors to treat metabolic disturbances of obesity

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专利权人:

The Trustees of Columbia University in the City of New York

发明人:

Tabas, Ira,Ozcan, Lale,Li, Gang,Montminy, Mark,Wang, Yiguo

申请号：

AU2012301617

公开号：

AU2012301617A1

申请日:

2012.08.31

申请国别(地区):

AU

年份:

2014

代理人:

摘要：

The present invention relates to methods of treating or preventing a metabolic disorder in a subject, methods of treating or preventing coronorary artery disease in a subject with a metabolic disorder, as well as methods of reducing hepatic glucose production in a subject. Such methods include, but are not limited to, the administration to the subject of inhibitors of CaMKII, IP3Rs, calcineurin, p38, MK2/3, or any combination thereof. The invention also provides methods of identifying a compound that inhibits the activity of CaMKII, IP3Rs, calcineurin, p38, or MK2/3, or reduces the activity and/or activation of CaMKII, IP3Rs, calcineurin, p38, or MK2/3.

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http://www.ckcest.cn/home/