INHIBITEURS DE CAMKII, IP3R, CALCINEURINE, P38 ET MK2/3 POUR TRAITER DES PERTURBATIONS METABOLIQUES DE L'OBESITE

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专利权人:

SALK INSTITUTE FOR BIOLOGICAL STUDIES;THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

发明人:

TABAS, IRA,OZCAN, LALE,LI, GANG,MONTMINY, MARC,WANG, YIGUO

申请号：

CA2857374

公开号：

CA2857374A1

申请日:

2012.08.31

申请国别(地区):

CA

年份:

2013

代理人:

摘要：

The present invention relates to methods of treating or preventing a metabolic disorder in a subject, methods of treating or preventing coronorary artery disease in a subject with a metabolic disorder, as well as methods of reducing hepatic glucose production in a subject. Such methods include, but are not limited to, the administration to the subject of inhibitors of CaMKII, IP3Rs, calcineurin, p38, MK2/3, or any combination thereof. The invention also provides methods of identifying a compound that inhibits the activity of CaMKII, IP3Rs, calcineurin, p38, or MK2/3, or reduces the activity and/or activation of CaMKII, IP3Rs, calcineurin, p38, or MK2/3.

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