SALK INSTITUTE FOR BIOLOGICAL STUDIES;THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
发明人:
GANG LI,IRA TABAS,LALE OZCAN,MARK MONTMINY,YIGUO WANG
申请号：
BR112014005104
公开号：
BR112014005104A2
申请日:
2012.08.31
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
abstract the present invention relates to methods of treating or preventing a metabolic disorder in a subject, methods of treating or preventing coronary artery disease in a subject with a metabolic disorder, as well as methods of reducing hepatic glucose production in a subject. such methods include, but are not limited to, the administration to the subject of inhibitors of camkii, ip3rs, calcineurin, p38, mk2 / 3, or any combination thereof. the invention also provides methods of identifying a compound that inhibits the activity of camkii, ip3rs, calcineurin, p38, or mk2 / 3, or the activity and / or activation of camkii, ip3rs, calcineurin, p38, or mk2 / 3. __________________________________________________________________________ abstract translation patent summary: "inhibitors camkii, ip3r, calcineurin, p38 and mk2 / 3 to treat binding metabolic disorders of obesity". The present invention relates to methods of treating or preventing a metabolic disorder in a subject, methods of treating or preventing coronary artery disease in a subject with a metabolic disorder, as well as methods of reducing hepatic glucose production in a subject. subject. Such methods include, but are not limited to, administering to the subject inhibitors of camkii, ip3rs, calcineurin, p38, mk2 / 3, or any combination thereof. The invention also provides methods of identifying a compound that inhibits the activity of camkii, ip3rs, calcineurin, p38, or mk2 / 3, or reduces the activity and / or activation of camkii, ip3rs, calcineurin, p38, or mk2 / 3. .abstract the present invention relates to methods of treating or preventing a metabolic disorder in a subject, methods of treating or preventing coronorary artery disease in a subject with a metabolic disorder, as well as methods of reducing hepatic glucose production in a subject. such methods include, but are not limited to, the administration to the subject of inhibitors of camkii, ip3rs, calcineurin, p38, mk2/3, or any combination there
