Disclosed is therapeutic use of an extract from rabbit skin inflamed by vaccinia virus. Particularly, disclosed is use of an extract from rabbit skin inflamed by vaccinia virus in treating hematopoietic system damage or pancytopenia induced by an anti-cancer therapy. Moreover, disclosed is use of an extract from rabbit skin inflamed by vaccinia virus in treating leukopenia induced by an anti-cancer therapy. Further, the extract from rabbit skin inflamed by vaccinia virus can be Lepalvir.