The present disclosure describes a medical imaging and/or visualization system and method that provide a user interface enabling a user to visualize (e.g., via a volume rendering) a three dimensional (3D) dataset, manipulate the rendered volume to select a slice plane, and generate a diagnostic image at the selected slice plane, which is enhanced by depth colorized background information. The depth colorization of the background image is produced by blending, preferably based on the depth of structures in the volume, two differently colorized volume renderings, and then fusing the background image with a foreground diagnostic image to produce the enhanced diagnostic image.